Eric's success as a substitute teacher leads to a new job opportunity.
The episode begins with Mrs. Garrison crying in front of her class as she recounts the story of Thomas Beatie, the pregnant transsexual man who appeared on The Oprah Winfrey Show a week before the episode's release. She claims that Beatie is still a woman deep down inside due to the fact he had a baby, meaning that Ms. Garrison herself is still a man deep down inside. She then explains that she is no longer happy as a "woman", but cannot return to being a man because his penis was destroyed after his sex-change operation in the episode "Mr. Garrison's Fancy New Vagina".
Ms. Garrison enlists the South Park Police to help find her runaway penis.
Garrison's penis rampages all over South Park, terrifying the local women.
Mr. Garrison and Cartman both find happiness.
Butter's mom finds a surprise in the kitchen.
Mr. Garrison's penis escapes from the genetics lab.
Ms. Garrison gives up her hopes of ever becoming a man again.
Ms.Garrison's dream to become a man again is given hope by a lab mouse and science.
One of Mr. Cartmanez's students needs his advice.
The mouse and Garrison's new penis sing under the moon and stars.
Ms. Garrison realizes that her sex change was a mistake.
Garrison's penis goes out for Italian.
Garrison is looking everywhere for his escaped penis.
The students recieve good news and bad news about their test scores.
Garrison is removed from his teaching duties and Cartman takes his place.
A troubled kid learns a painful lesson from Mr. Cartmanez.
The students begin to trust Mr. Cartmanez.
Eric Cartmanez starts his first day as a Calculus teacher in the inner-city.
Cartman teaches the inner-city kids how to use the white person method.